Witt, Pharm.D., FCCP, BCPS, served on the ASH guideline panel.

Clark, Pharm.D., FCCP, BCPS, and Daniel M. Conditional recommendations include a preference for home treatment for uncomplicated DVT and PE in patients at low risk of complications and a preference for direct-acting oral anticoagulants over vitamin K antagonists for primary treatment of VTE. The panel issued strong recommendations for the use of thrombolytic therapy in patients with a PE resulting in hemodynamic compromise, use of an international normalized ratio (INR) goal of 2.0–3.0 in patients with a history of venous thromboembolism (VTE) who are treated with a vitamin K antagonist for secondary prevention, and use of anticoagulation for an indefinite period in patients with recurrent unprovoked VTE. The 2020 guideline, created by a multidisciplinary global panel, provides 28 recommendations for the initial management of venous thrombosis as well as primary treatment, secondary prevention, and treatment of recurrent thrombotic events. The American Society of Hematology (ASH) has issued a new guideline for the treatment of deep venous thrombosis (DVT) and pulmonary embolism (PE).

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